Preprints:

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Wu, Y., Wierda, K., Vints, K., Huang, Y-C., Uytterhoeven, V., Loomba, S., Laenen, F., Hoekstra, M., Dyson, M.C., Huang, S., Piao, C., Chen, J., Banala, S., Chen, C-C., Baz, E-S., Lavis, L., Dickman, D., Gounko, N.V., Sigrist, S., Verstreken, P., Liu, S. (2025) Presynaptic Release Probability Determines the Need for Sleep. bioRxiv 2025.10.16.682770

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Chen, C-C., Huang, Y-C., Ortega, A., Suarez-Grimalt, R., Tedre, E., Baz, E-S., Wu, Y., Lin, A., Liu, S. (2025) Sleep Facilitates Pattern Separation through SK Channel-Mediated Sparse Coding. bioRxiv 2025.10.08.681112​

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Ortega, A., Tedre, E., Baz, E-S., Tsao, C-H., Chen, C-C., Liu, S. (2024) A High-Throughput Platform for Assessing Single Fly Learning and Memory: Individual Drosophila Olfactory Conditioner (iDOC). bioRxiv 2024.12.18.629135​

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Peer-reviewed Research:​

 

Dopp, J., Martens, S., Hobin, F., Mastroianni, S., Yan, J., van Ninhuys, L., Mauletkhan, A., Liu, S. (2026). Genetic targeting of astrocytes associated with specific neuronal circuit in adult Drosophila. Cell Rep Methods (In press)​

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Li, L., Yan, J., Ruan, Y., Dyson, M.C., Laene, F., Liu, S.*, Xie, X.* (2025) dFlpTag, a RMCE-based tool for simultaneous endogenous protein tagging and cell labeling in Drosophila. Sci Rep 15, 45542. (* co-corresponding authors).

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Dopp, J., Ortega, A., Davie, K., Poovathingal, S., Baz, E-S., Liu, S. (2024). Single-cell transcriptomics reveals that glial cells integrate homeostatic and circadian processes to drive sleep-wake cycles. Nat Neurosci 27(2):359-372

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Chowdhury, B., Abhilash, L., Ortega, A., Liu, S., Shafer, O.T. (2023).  Homeostatic Control of Deep Sleep in Drosophila: Implications for Discovering Correlates of Sleep Pressure. eLife 12:e91355.

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Ho, M.C.W., Tabuchi, M., Xie, X., Brown, M., Luu, S., Wang, S., Kolodkin, A., Liu, S., Wu, M.N. (2022).  Sleep Need-Dependent Changes in Functional Connectivity Facilitate Transmission of Homeostatic Sleep Drive. Curr Biol 32(22):4957-4966.

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Blum, I.D., Keles, M.F., Baz, E-S., Han, E., Park, K., Luu, S., Issa, H., Brown, M., Ho, M.C.M., Tabuchi, M., Liu, S.*, Wu, M.N.* (2021). Astroglial Calcium Signaling Encodes Sleep Need in Drosophila. Curr Biol 31(1):150-162. (* co-corresponding authors). (Previewed in Current Biology)

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Tabuchi, M., Monaco, J.D., Duan, G., Bell, B., Liu, S., Liu, Q., Zhang, K., Wu, M.N. (2018).  Clock-Generated Temporal Codes Determine Synaptic Plasticity to Control Sleep. Cell 175(5):1213-1227. (Previewed in Cell)

 

Davie, K., Janssens, J., Koldere, D., De Waegeneer, M., Pech, U., Kreft, L., Aibar, S., Makhzami, S., Christiaens, V., Gonzalez-Blas, C.B., Poovathingal, S., Hulselmans, G., Spanier, K.I., Moerman, T., Vanspauwen, B., Geurs, S., Voet, T., Lammertyn, J., Thienpont, B., Liu, S., Konstantinides, N., Fiers, M., Verstreken, P., Aerts, S. (2018) A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain. Cell 174(4):982-998. (Previewed in Cell)

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Before VIB-KU Leuven:

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Liu, Q., Tabuchi, M., Liu, S., Kodama, L., Horiuchi, W., Daniels, J., Chiu, L., Baldoni, D., Wu, M.N. (2017) Branch-Specific Plasticity of a Bifunctional Dopamine Circuit Encodes Protein Hunger. Science 356 (6337):534-539.

 

Liu, S., Liu, Q., Tabuchi, M., Wu, M.N. (2016). Sleep Drive is Encoded by Neural Plastic Changes in a Dedicated Circuit. Cell 165(6):1347-1360.  (Previewed in Cell, Recommended by Faculty of 1000)

 

Tabuchi, M., Lone, S.R., Liu, S., Liu, Q, Zhang, J., Spira, A.P., Wu, M.N. (2015). Sleep Interacts Synergistically with Aβ to Modulate Intrinsic Neuronal Excitability. Curr Biol 25(6):702-712.  (Previewed in Current Biology)

 

Riabinina, O., Luginbuhl, D., Marr, E., Liu, S., Wu, M.N., Luo, L., Potter, C.J. (2015). Improved and Expanded Q-system Reagents for Genetic Manipulations. Nat Methods 12(3):219-222.

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Liu, S., Lamaze, A., Liu, Q., Tabuchi, M., Yang, Y., Fowler, M., Bharadwaj, R., Zhang, J., Bedont, J., Blackshaw, S., Lloyd, T.E., Montell, C., Sehgal, A., Koh, K., Wu, M.N. (2014).  WIDE AWAKE Mediates the Circadian Timing of Sleep Onset. Neuron 82(1):151-166.

 

Jepson, J.E.C., Shahidullah, M., Liu, D., Marchand, S.J., Liu, S., Wu, M.N., Levitan, I.B., Dalva, M.B., Koh, K. (2014). Regulation of synaptic development by the Drosophila PDZ domain protein DYSCHRONIC. Development 141(23):4548-4557.

 

Liu, Q., Liu, S., Kodama, L., Driscoll, M.R., Wu, M.N. (2012). Two Dopaminergic Neurons Signal to the Dorsal Fan-shaped Body to Promote Wakefulness in Drosophila. Curr Biol 22(22):2114-2123.  (Previewed in Current Biology)

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